Manufacturing of Transdermal Therapeutic Systems
In the second step, the liquid, adhesive matrix is applied evenly to the release liner. This is important so as to ensure that precisely the same concentration of the active substance is present at every point on the LTS patch. As a result, this stage of production is rather complex and time-consuming.
The matrix is then carefully dried and fixed to the release liner.
A simple form of the patch has now been created. In the next step, the backing film is applied to the dried matrix. This creates a ‘patch’ measuring 1.5 metres across and up to 300 metres in length.
This enormous patch, called the laminate (comprising release liner, adhesive layer and backing film), is then cut to size.