Oral Thin Films

Oral thin films are loaded with active substances. The Thin films are taken orally and dissolve immediately in the mouth or are applied to the mucosa. For transmucosal films, the active substance enters the bloodstream directly via the oral mucosa, without having to first pass through the gastrointestinal tract.

Oral thin films (OTF) are thin, flexible films for drug delivery. They are placed on or under the tongue, where they then dissolve. Transmucosal films are absorbed by the body directly via the oral mucosa. The excellent blood supply to the oral mucosa means the active substance enters the bloodstream immediately.

Diverse technologies for wide-ranging applications

Various LTS OTF technologies enable fast or sustained release of the active substance, thus ensuring the ideal dosage.

LTS OTFs measure between 2 and 10 cm2 and are extremely thin (20 to 500 µm). These thin films can take the form of a single-layer or multi-layer system. The active substance can be dissolved in the matrix, emulsified or dispersed. If necessary, it can also be bound as a complex in order to mask taste, for example.

Fast Disintegrating Buccal Film

Non-Disintregating Buccal Film

Non-Disintegrating Buccal Film

Melt Away Film

Melt Away Film

Melt Away Film with Taste Masking Agents

Melt Away Film with Taste Masking Agents

The advantages of OTFs

For patients:

  • safe, reliable, precise and pain-free application
  • discreet and easy application
  • can be taken without extra water
  • ideal for when patients are on the go
  • easier to treat children, as well as older patients and patients requiring complex care
  • ideal for patients who have difficulty swallowing


For pharmaceutical companies:

  • possible avoidance of the first-pass effect
  • improved bioavailability
  • potentially requires lower amounts of active substances than tablets or solutions
  • controlled application of the required dose
  • improved compliance on the part of patients
  • more options for differentiating a product range
  • innovative and appealing design
Erkrankung/Einsatzbereich Wirkstoff Medikament
Allergy/Cough and Cold Dextromethorphan HBr
Diphenhydramin HCl
Smoking cessation Nikotin N Niquitin®
Alzheimer‘s disease Donepezil HCl Donepezil-HCl
Antiemetic Ondansetron Setofilm®
Pain Management Fentanyl Onsolis®
Pain Management Buprenorphin/Naloxon Suboxone®
Neuroleptic Risperidon Risperidone
Anti-flatulence Simethicon Gas-X®

green = manufactured by LTS